Methods of Information in Medicine is an official journal of the International Medical Informatics Association (IMIA), of the European Federation of Medical Informatics (EFMI) and the international official journal of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS, in German only). Methods of Information in Medicine is directed towards the methodology and scientific fundamentals of organizing, representing and analyzing data, information and knowledge in biomedicine and health care. Publications include new methods in biomedical and health informatics, biomedical statistics and epidemiology covering biomedically and clinically motivated approaches for • Information documentation, storage, and retrieval • Knowledge management and discovery • Data integration and interoperability • Natural language processing and text mining • Statistical modeling and analysis • Data linkage • Predictive modeling and simulation • Software engineering and evaluation