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Indicated for: Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome (as adjunctive therapy to continuous positive airway pressure), Shift Work Sleep Disorder, Headache, Nausea, Anxiety, Dizziness, Insomnia, Diarrhea.

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American investigators have demonstrated that the elimination half-life of modafinil is prolonged by approximately thirty to forty percent in healthy adults over age sixty-five compared to younger control populations, resulting in extended duration of wakefulness-promoting effects that may approach twelve to fourteen hours following a single 100 mg or 200 mg dose. The American Academy of Sleep Medicine clinical practice guidelines for the pharmacologic treatment of central disorders of hypersomnolence explicitly recommend against routine use of MODALERT at dosages exceeding 200 mg daily, citing the absence of efficacy data and the well-characterized dose-response relationship that plateaus at the standard therapeutic dosage. United States patients who achieve optimal response to adjunctive MODALERT therapy report not only reduced sleepiness but also improvements in mood, cognitive function, and overall quality of life that represent meaningful therapeutic benefits extending beyond simple wakefulness promotion. Medication Shift Work Sleep Disorder. The comparative efficacy and safety profiles of Adderall and MODALERT have been most rigorously characterized in the narcolepsy population, with United States National Institutes of Health-funded multicenter trials providing level one evidence informing clinical practice guidelines.

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American patients are counseled that consuming energy drinks later in the day may compound MODALERT's mild alerting effects in the evening, leading to difficulty falling asleep and reduced total sleep time, which can paradoxically worsen daytime sleepiness. The United Kingdom summary of product characteristics for MODALERT provides detailed information regarding optimal administration, including specific guidance that the tablet should be swallowed whole with water and that consistent administration relative to meals optimizes the predictability of therapeutic effect. Pills For Alertness No Delays, Just Action. The question of the difference between MODALERT and Modvigil requires understanding that both are brand names for modafinil manufactured by different pharmaceutical companies, primarily in India, and marketed in various regions around the world.

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