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However, with other classes, such as monoamine oxidase inhibitors (MAOIs), the combination could pose a serious risk of hypertensive crisis or serotonin syndrome, a potentially life-threatening condition characterized by agitation, high fever, and rapid heart rate. However, in a subset of individuals, it can potentially contribute to or unmask depressive symptoms. Modafinil is a potent inducer of the liver enzyme CYP3A4. Best Generic Provigil. This is closely related to how long the substance remains detectable, which addresses the query of how long does Provigil stay in your system, a period that can extend up to several days based on individual metabolism.

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