Resume
Publications
Citations
Researcher
ORCID: 0000-0002-0597-7940
Frank
Alexis
Full Professor at Yachay Tech
Biological Sciences and Engineering
Citations
5,545 / 10,977
Contact Info
Resume
Publications
Citations
Research Interests
Biomaterials
Nanotechnology
drug delivery
Bioimaging
Pharmaceuticals
Agrotechnology
Polymers
Metrics Overview
Publications
158
Since 2002
Citations
5,545 / 10,977
Worldwide
Avg. Citations
69
Per publication
G-Index
29
In past 5 years
Research Experience
Interim Vice Chancellor of Research and Innovation
Yachay University for Experimental Technology and Research|December 2019 - Present
Full Professor (Principal 3)
Yachay University for Experimental Technology and Research|August 2017 - Present

School of Biological Sciences and Engineering

Interim Vice Chancellor of Research and Innovation
Yachay University for Experimental Technology and Research|January 2019 - September 2019
Interim Chancellor
Yachay University for Experimental Technology and Research|October 2019 - December 2019
Adjunct Associate Professor
Clemson University|May 2017 - May 2018

Department of Bioengineering

Associate Professor
Clemson University|September 2015 - August 2017

Tenured Position-Department of Bioengineering

Visiting Associate Professor
Nanyang Technological University Singapore|May 2015 - August 2017

School of Chemical and Biomedical Engineering

Assistant Professor
Clemson University|May 2009 - August 2015

Department of Bioengineering

Postdoctoral Fellow
Brigham and Women S Hospital Boston|August 2006 - May 2009

Polymeric Nanoparticle Drug Delivery Systems

Research Associate
Massachusetts Institute of Technology|August 2006 - May 2009

Polymeric Nanoparticle Drug Delivery Systems

Research Scientist
Institute of Bioengineering and Nanotechnology-AStar-Singapore|September 2003 - August 2006

Non-Viral Gene Delivery

Work Experience
Chief Scientific Officer
GearJump Technologies LLC|August 2017 - Present
Consultant
Polymed Inc.|January 2015 - May 2017

Assisting for the development of novel drug delivery product.

Consultant
LEK Consulting|July 2014 - August 2014

Assisted for providing insights qbout oral drug delivery technologies.

Consultant
Stericoat Inc|January 2008 - December 2008

Assisted for the development of novel implant coatings.

Education
Nanyang Technological University Singapore
2000 - 2005
Doctoral Degree , Materials Science Engineering.

Drug Release and Degradation Mechanisms of Biodegrable Stents

Technological University of Montpellier (France)
1999 - 2000
Master's Degree , Materials Science and Interfaces
Technological University of Montpellier (France)
1995 - 1999
Bachelor's Degree , Chemistry
Presentations/Talks
54 Presentations in Conferences /Symposiums
Everywhere
54

 

 

2019

  1. Frank Alexis, "Research at Yachay Tech", Humboldt Symposium, Ibarra, Ecuador, 22 Feb. 2019.
  2. Frank Alexis, "From Synthetic to Natural Materials", Humboldt Workshop, Ibarra, Ecuador, 17 Feb. 2019.
  3. Frank Alexis, "Natural fibers with chemical and biological activity", NSSY 2019, Galapagos, Ecuador.
  4. M Ateia, M Attia, N Tharayil, F Alexis, D Whitehead, T Karanfil Near-instant removal of poly-and perfluorinated alkyl substances by polyethylenimine-functionalized cellulose microcrystals, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257

2018

  1. Frank Alexis, "Biomaterials and Biomedicine", Jornadas de Biologia, Salinas, Ecuador, 21 Nov. 2018.
  2. Frank Alexis, "Biomaterials as Immunostimulant in Aquaculture to Prevent Vibriosis", Jornadas de Biologia, Salinas, Ecuador, 21 Nov. 2018.
  3. Frank Alexis,"Nanomaterials for the remediation of gas and water pollutants", VI Congreso ReDU, Ibarra, Ecuador, 6 Nov. 2018.

2017

  1. Frank Alexis, Charles Rice, "Structural feed complement as Immune-Stimulant in Aquaculture", XIX Congreso Ecuatoriano de Acuicultura, Salinas, Ecuador, 24-28 Nov. 2017.
  2. Frank Alexis, "Nanomaterials for the Remediation of Pollutants", Congreso Internacional de Biotecnologia, Ibarra, Ecuador, 13-15 Dic. 2017.
  3. G Schober, D Benza, U Uzair, H Chen, D Colvin, J Gore, J Tzeng, F Alexis, “Chemical sensing using radioluminescent phosphors”, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254

2016

  1. Michael Taylor, K B. Acampora, Joel T. Corbett, Frank Alexis, Bradley R. Johns and 1

2015

  1. S Nicolau, L Davis, C Duncan, T Olsen, F Alexis, D Whitehead, “Well-defined poly (epsilon-caprolactone) for X-ray imaging materials via oxime click reactions” ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250

2014

  1. Olsen, T., Casco, M., Simionescu, D., Visconti, R., Alexis, F.”Accelerating Cellular Spheroid Fusion Using Magnetic Forces to Fabricate a Vascular Tissue "Blood Vessel Tissue Engineering", Accepted. Biomedical Engineering Society, San Antonio, Accepted (2014).
  2. Olsen, T., Whitehead, D., Van Horn, B., Alexis, F. ”Non-Invasive Deep Tissue Imaging of Polymer Degradation Using X-Ray”, Accepted. Biomedical Engineering Society, San Antonio, Accepted (2014).

2013

  1. Alexis, F. “Drug Delivery and Imaging Technologies Using X-Ray”, ICMAT, Singapore, (2013).
  2. Olsen, T., Alexis F.; “Cellular Spheroid Fusion Using Magnetic Forces to Fabricate a Vascular Tissue”, Society For Biomaterials, (2013).
  3. Moore, T.; Mattix, B.; Grimes, S.; Dhulekar, J.; Kraveka, J.; Frankel, B.; Alexis, F. “Delivery of Non-toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer Therapy.” SC INBRE Symposium, Columbia, (2013).
  1. Moore, T.; Wang, F.; Morrison, R.; Musgrave, L.; Anker, J.N.; Alexis, F. “Radioluminescent Polymer Coated Nanoparticles for Imaging Drug Delivery to the Brain.” SC INBRE Symposium, Columbia, (2013).           
  2. Mattix, B.; Uvarov, O.; Pollard, S.; O’Donnell, L.; Park, K.; Horne, D.; Dhulekar, J.; Kraveka, J.; Frankel, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment for Drug Delivery Applications.” SC INBRE Symposium, Columbia, (2013).
  3. T Moore, R Podila, F Alexis, A Rao, Graphene for Biomedical Implants, APS Meeting Abstracts

 

2012

  1. Mattix, B., Uvarov, O., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment”, Proceedings of the SC INBRE Scientific Symposium, Columbia, SC, (2012).
  2. Mattix, B., Reese, L., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L., Bruce, T., Alexis, F. “Assembly of Engineered Blood Vessels Using Magnetic Forces.” Proceedings of the SC Project for Organ Biofabrication Scientific Symposium, Columbia, SC, (2012).
  3. Poole, T., Mattix, B, Reese, L., Alexis, F. “Magnetic Spheroids For Tissue Engineering Applications.” Proceedings of the National Conference on Undergraduate Research, Weber State University, Ogden, Utah, (2012).
  4. Wright-Walker, C. J.; Golightly, C. E.; Alexis, F.; DesJardins, J. D.;  LaBerge, M.; “Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight
    Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”;
    Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
  5. Moore, T. L.; Stoner, B.; Morrison, R.; Simionescu, A.; Simionescu, D.; Recknor, C.; Alexis, F.; “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic Bone Therapy Drugs”. Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
  6. Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.;  Simionescu, D.; Simionescu, A.;
    Alexis, F.; “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue Engineered Building Blocks”. Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
  7. Dawson, B.; “Periorbital Implant for Treatment of Cytomegalovirus”. Proceedings of the South Carolina-Louis Stoke Alliance for Minority Participation (LSAMP) Conference, Columbia, (2012).
  8. Horne, D.; “Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment”. Proceedings of the South Carolina-Louis Stoke Alliance for Minority Participation (LSAMP) Conference, Columbia, (2012).
  9. Alexis, F.; “Polymer Coated CNTs to Safely Delivery Drugs”. Proceedings of the ACS SERMACS Meeting, Raleigh, (2012).
  10. Uvarov, O.; Mattix, B.; Pollard, S.; O’Donnel, L.; Horne, D.; Dhulekar, D.; Frankel, B. Alexis, F.”An Investigation of Functionalized Nanoparticles Interactions with Brain Cancer Cells” .I”. Proceedings of the ICMAT, Singapore, (2012)
  11. Moore, T.; Morrison, R.; Stoner, B.; Simionescu, A.; Simionescu, D.; Recknor, C.;  Alexis, F. “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic Bone Therapy Drugs.”Proceedings of the Biomedical Engineering Society Annual Meeting, Atlanta, (2012).
  12. Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.;  Simionescu, D.; Simionescu, A.;
    Alexis, F. “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue Engineered Building Blocks”. Proceedings of the Biomedical Engineering Society Annual Meeting, Atlanta, (2012).
  13. Chen H., Moore T., Qi B., Colvin D.C., Jelen E., Hitchcock, D., He J., Mefford O.T., Gore J.C., Alexis F., Anker J.N., “Monitoring pH-triggered drug release from radioluminescent nanocapsules with X-ray excited optical luminescence,” Proceedings of the ACS SERMACS Meeting, Raleigh, (2012).
  1. Uvarov, O., Mattix, B., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F.” Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment”, SFB- Memphis Biomaterials Day, University of Memphis, Memphis, TN, (2012).
  2. Moore, T.L.; Britton, T.; Jelen, E.; Mattix, B.; Frankel, B.; Alexis, F.; “Delivery of Non-toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer Therapy”. SCBIO Conference, Charleston, (2012).
  3. Mattix, B.; Poole, T.; Casco, M.; Visconti, R.; Simionescu, D.; Simionescu, A.; Alexis, F. “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue Engineered Building Blocks”. SCBIO Conference, Charleston, (2012).
  4. Moore, T.; Podila, R.; Rao, A.; Alexis, F. “Graphene Coated Technology for Biomedical Implants.” SFB- Clemson University Biomaterials Day, Clemson, (2012).
  5. Casco, M.; Poole, T.; Visconti, R.; Simionescu, D.; Simionescu, A.; Mattix, B.; Alexis, F. “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue Engineered Building Blocks.” SFB- Clemson University Biomaterials Day, Clemson, (2012).
  6. Uvarov, O.; Willi, T.J.; Reese, L.; Pollard, S.; O’Donnell, L.; Horne, D.; Dhulekar, J.; Frankel, B.; Mattix, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment.” SFB- Clemson University Biomaterials Day, Clemson, (2012).
  1. R Podila, T Moore, JM Brown, F Alexis, AM Rao, “Nanocarbon platforms for implant coatings and probing protein corona” ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244

2011

  1. Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules to Target Bone”, Proceedings of the National Conference of Undergraduate Research, Ithaca College, Ithaca, NY, (2011).
  2. Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules to Target Bone”, Proceedings of the ACC Meetings of Minds, University of Miami, Miami, FL, (2011).
  3. Keith, K., Mattison, S., Collier, M., Lewis, R., Alexis, F. “Testing Chemotherapeutic Drugs for Synergistic Toxicity Using Several Cancer Cell Lines”, Proceedings of the ACC Meetings of Minds, University of Miami, Miami, FL, (2011).
  4. Wright-Walker, C. J., DesJardins, J. D., Alexis, F., LaBerge, M., “Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”, Proceedings of the Society For Biomaterials Meeting, Orlando, FL, (2011).
  5. Mattix, B., Reese, L., Pollard, S., Anderson, J., Carpenter, K., Davda, L., Breece, J., Alexis, F.”Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Cancer Cells”, Proceedings of the Southeast Regional IDeA Meeting, New Orleans, LA, (2011).
  1. Moore, T., Przestrzelski, B., Lewis, R., Jelen, E., Dhulekar, J., Stoner, B., Bloomquist, C., Simionescu, D., Simionescu, A., Recknor, C., Alexis, F. “Targeted Nanoparticles to Deliver Drugs for Prolonged Periods of Time to Bone Tissue.”, SCMEDTECH Conference, Charleston, SC, (2011).
  2. Stoner, B., Morrison, R., Przestrzelski, B., Dhulekar, J., Lewis, R., Jelen, E., Moore, T., Simionescu, D., Simionescu, A., Recknor, C., Alexis. F., “Targeted Nanoparticles to Deliver Drugs Through Controlled Release Kinetics to Bone Tissue”, SFB-Memphis Biomaterials Day, University of Memphis, Memphis, TN, (2011).
  3. Reese, L., Mattix, B., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L., Bruce, T., Alexis, F., “ Magnetic Cell Spheroid For Tissue Engineering Applications”, SFB-Clemson University Biomaterials Day, Clemson University, Clemson, SC, (2011).
  4. Poole, T., Mattix, B., Reese, L., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L. Bruce, T., Alexis, F., “Magnetic Spheroids For Tissue Engineering Applications”, Southeast Biomedical Engineering Career Conference, University of Virginia, Herndon, VA, (2011).

2010

  1. Banik, B.L., Rogers, M., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules to Target Bone”, Southeast Biomedical Engineering Career Conference, Clemson, SC, (2010).

2007

  1. Alexis, F., “HER-2 Targeted Nanoparticle-Affibody Bioconjugates for Breast Cancer Therapy”, Proceedings of the American Association Cancer Research Annual Meeting, Los Angeles, CA, (2007).
  2. Alexis, F., “HER-2 Targeted Polymeric Nanoparticles for Breast Cancer Therapy”, Proceedings of the Nano Science and Technology Institute Conference, Santa Clara, CA, (2007).

2003

  1. Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Comparative Study of Drug Release from Matrices Made of PLLA and PLGA Copolymers”; Proceedings of the International Conference on Materials for Advanced Technologies, Singapore, Singapore, (2003).

2002

  1. Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Factors Affecting the Drug Release Mechanisms of PLGA 53/47 and PLLA”, Proceedings of the International Conference of Materials Processing for Properties and Performance (MP3), Singapore, Singapore, (2002).
Patents
Inventors
Ulrich H Von Andrian, Omid C Farokhzad, Robert S Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
Publication date
2020/2/20
Patent office
US
Application number
16544464
Inventors
Omid C Farokhzad, Frank Alexis, Timothy T Kuo, Eric Pridgen, Aleksandar Filip Radovic-Moreno, Robert S Langer
Publication date
2018/11/1
Patent office
US
Application number
16027121

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

EM Pridgen, F Alexis, OC Farokhzad, RS Langer, RS Blumberg
US Patent App. 15/039,770

Adjuvant incorporation in immunoanotherapeutics

F Alexis, M Iannacone, J Shi, P Basto, EA Moseman, U Von Andrian, ...
US Patent 9,439,859

Biodegradable waste remediation method and system

DC Whitehead, F Alexis
US Patent App. 15/012,991

Amphiphilic compound assisted nanoparticles for targeted delivery

L Zhang, AF Radovic-Moreno, FX Gu, F Alexis, RS Langer, OC Farokhzad
US Patent 9,333,179

Targeting of antigen presenting cells with immunonanotherapeutics

J Shi, F Alexis, M Iannacone, EA Moseman, P Basto, RS Langer, ...
US Patent 9,308,280

Targeting of antigen presenting cells with immunonanotherapeutics

J Shi, F Alexis, M Iannacone, EA Moseman, P Basto, RS Langer, ...
US Patent 9,308,280

X-ray Excited Optical Materials and Methods for High Resolution Chemical Imaging

J Anker, C Hongyu, F Alexis
US Patent App. 14/795,399

Biodegradable polyester-and poly (ester amide) based x-ray imaging agents

F Alexis, DC Whitehead, BA Van Horn
US Patent App. 14/683,775

Nicotine immunonanotherapeutics

M Iannacone, U Von Andrian, OC Farokhzad, F Alexis, P Basto, J Shi, ...
US Patent 8,932,595

Immunonanotherapeutics that provide IGG humoral response without T-cell antigen

M Iannacone, F Alexis, P Basto, EA Moseman, J Shi, RS Langer, ...
US Patent 8,906,381

Delivery System for Enhancing Drug Efficacy

F Alexis, B Frankel
US Patent App. 13/784,930

Oligonucleotide systems for targeted intracellular delivery

OC Farokhzad, E Levy-Nissenbaum, RS Langer, F Alexis
US Patent App. 12/376,005

Poly (amino acid) targeting moieties

F Alexis, L Zhang, AF Radovic-Moreno, FX Gu, P Basto, ...
US Patent App. 12/098,354
Prizes and Awards
2nd Best Oral Presentation
Jornadas de Biologia | Apr 2018
Recognition for exceptional service and support
PEER& WISE | Sep 2017
Mentor of the Year
Louis Stoke South Carolina Alliance for Minority Participation- | May 2016
Top Translational Junior Faculty
Listed in a Nature Biotechnology | May 2013