Interests: Common neuropathologist of aging & cognitive decline & modifying potential of medication and lifestyle. Setting: population-based cohorts of aging with brain autopsies. Methods: Observational and epidemiology, neuropathology, immunohistochemistry and I collaborative biochemical, proteomic and genetics. Current work: co-morbidity and microvascular brain injury in ADNI, CCNA and the Douglas-Bell Canada Brain Bank.