Resume
Researcher
ORCID: 0000-0003-1100-9177
ResearcherID: ABH-6814-2020
Yang
Jiang
Assistant Research Professor at Pennsylvania State University
Department of Chemistry
State College, PA, United States
Citations
-
Contact Info
Resume
Professional Skills
Add your professional skills.
Work Experience
Penn State University
Full-time · 4 yrs 6 mos - Present
United States
• Developed a machine-learning guided biophysical modeling method to investigate the mechanistic features dictating ribosome catalysis. • Design small molecule drugs that can rescue misfolded entangled proteins.Skills: Visualization · Protein Structure · Computational Biology · Structural Biology · Scientific Research · Biology · Scientific Writing · Homology Modeling · Chemistry · Biophysics · Biochemistry · Quantum Mechanics · Database Applications · High Performance Computing (HPC) · Python (Programming Language) · Molecular Modeling · Molecular Dynamics · Computational Chemistry · Computational Biophysics · Multiscale Modeling• Developed a multiscale model for protein translation and folding (QM/MM up thru coarse-grained modeling). • Discovered a new, wide-spread class of protein misfolding in E. coli cytosolic proteome, some of which act as a molecular bridge connecting synonymous mutations to long-timescale changes in protein structure and function. • Studied molecular mechanisms of how interactions between ribosome and nascent chain modulates protein translation and folding.Skills: Visualization · Protein Structure · Computational Biology · Structural Biology · Scientific Research · Biology · Scientific Writing · Homology Modeling · Chemistry · Biophysics · Biochemistry · Quantum Mechanics · Database Applications · Gaussian 03 · High Performance Computing (HPC) · Python (Programming Language) · Molecular Modeling · Molecular Dynamics · Computational Chemistry · Computational Biophysics · Multiscale Modeling
Graduate Research Assistant
Beijing University of Chemical Technology September 2012 - June 2018
China
Advisor: Prof. Tianwei Tan. • Developed a set of force field parameters for metal ions that have outstanding performance in modeling metalloenzymes. • Demonstrated the molecular mechanism of competitive guest encapsulation of a coordination-directed self-assembly M2L4 nanocapsule. • Demonstrated the molecular mechanism of the conformational changes in solvent environment for Yarrowia lipolytica lipase. This work resulted in 12 publications in J. Phys. Chem. Lett., J. Chem. Theory Comput., J. Chem. Inf. Model., and J. Phys. Chem. B, etc.Skills: Visualization · Protein Structure · Computational Biology · Scientific Research · Biology · Scientific Writing · Homology Modeling · Chemistry · Biophysics · Biochemistry · Quantum Mechanics · Database Applications · Cheminformatics · QSAR · Gaussian 03 · High Performance Computing (HPC) · Molecular Modeling · Molecular Dynamics · Computational Chemistry · Computational Biophysics
Education
Beijing University of Chemical Technology
Sep 2012 - Jun 2018
Chemical Engineering and Technology
Beijing University of Chemical Technology
Sep 2008 - Jun 2012
Information and Computing Science
Realted Researchers